Prehospital Airway Management: To Intubate or Not to Intubate

David Lobel MD FACEP, Medical Director, Ambulance Department, Maimonides Medical Center

Endotracheal intubation has been in use by paramedics for nearly two and a half decades, yet as medicine in general and emergency medicine in specific have become progressively more evidence based, this practice has been the subject of scrutiny and debate. The 2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care specifically recommends bag-valve mask ventilation for infants and children, stating that it as effective as endotracheal intubation for short periods of time, and may be safer.1 As emergency physicians, whether we serve as EMS medical directors or not, we share responsibility of providing oversight and quality assurance for prehospital care. The following is a critical review of the evidence to date and a discussion of the future of endotracheal intubation in the prehospital setting.

Success of endotracheal intubation by paramedics has been studied extensively.2-5,7-16 Rates of successful intubation by paramedics in the field have been reported as high as 98.4%, but are more commonly in the 80-90% range. Wang and colleagues looking prospectively at 783 patients with attempted intubation across advanced life support services in urban, suburban, rural and air medical settings report an overall success rate of 86.8%. The success rate for cardiac arrest victims was reported at 92.8% and dropped to 76.8% in non-arrest patients. Ninety-eight percent is a laudable success rate in many accomplishments, but when that translates to almost two of every 100 patients not having a definitive airway, we must consider if that even approaches an adequate success rate. In the study of 2,614 prehospital intubations in which Bulger et al.2 cited that 98.4% success rate, 12 patients received paralytics without achieving airway access.

Drs. Wang and Yealy13 analyzed the data more closely, looking not only at success rate, but at success rate by number of attempts. In a prospective study of 42 EMS agencies over an 18-month period, complete data were available for 1,941 cases. The cumulative overall success rate was 91.8% after three attempts with nearly 30% of patients requiring more than one attempt at ETI. The authors noted slightly higher success rates with patients in cardiac arrest, but also noted slightly lower success rates in patients who received RSI, and significantly lower success rates (77% cumulative) in patients in whom sedation facilitated intubation was performed. The article notes that multiple attempts at ETI are associated with complications that include hypoxemia, airway trauma, bradycardia and cardiac arrest. Furthermore, field intubation may increase the time on scene, delaying care for underlying injury or illness.14

Dunford et al.,8 looked specifically at the complications of “rapid sequence intubation.” Using continuous recordings of oxygen saturation and heart rate during prehospital ETI with RSI, they observed that 57% of patients experienced desaturation. Desaturation was defined as oxygen saturation less than 90% in patients whose baseline had been above 90% or a decline from baseline if the initial saturation with basic life support interventions had been less than 90%. The median time of desaturation was 160 seconds, with a median decrease in oxygen saturation of 22%. Significant alterations in pulse rate were also noted in the study group. While 61% of patients experienced a drop in pulse of 20 bpm or more, 19% experienced profound bradycardia, defined as a heart rate less than 50 bpm. An additional 29% of these patients experienced an increase in pulse of 20 bpm or more. In the vast majority of patients who experienced desaturation (84%) paramedics described the intubation as “easy.”

One of the most significant areas to receive attention in this area is outcomes data. In a controlled clinical trial that compared survival and neurological outcome in children requiring airway management, Gausch et al.4 found no statistically significant difference overall in survival and neurological outcome between the group treated with ETI versus those managed with bag-valve mask ventilation (analysis based on intent to treat). In a subgroup analysis the authors noted significant worsening in survival or neurological outcome in patients with a final diagnosis of respiratory arrest, child maltreatment, or foreign body aspiration when treated with ETI. A similar outcomes analysis looked at the use of rapid sequence intubation in severe traumatic brain injury.5 Davis et al. looked at 209 patients with severe head injury and matched each patient with three controls with similar injury severity from the trauma registry. The authors found that mortality was significantly increased in the trial cohort, and incidence of good outcomes decreased. The authors attributed these findings to transient hypoxia, inadvertent hyperventilation, and longer on-scene times among other factors.

In many EMS systems, paramedics have little experience with intubation,15 at the same time it is recommended that regular experience with ETI along with rigorous training and close monitoring of a limited number of providers are the cornerstones of a successful program.16 The Bulger study2 out of Seattle which reports the single highest success rate for prehospital intubation, specifically state that their paramedics have over 3,000 hours of advanced medical training, with ongoing operating room access, quarterly training sessions, and animal labs which are repeated every two years. The EMS in that study also has a minimum requirement of 12 intubations annually by each medic to maintain credentialing. This level of training and oversight is neither possible nor practical in all settings.

In implementing an EMS system that includes prehospital ETI protocols the medical director must weigh what conditions warrant advanced airway management (possibly burns and drowning) and which conditions are better served by rapid transit with non-invasive ventilatory techniques (e.g. head injury, trauma). Protocols that specify that endotracheal intubation should only be employed if less invasive techniques are not effective, encourage the use of non-invasive ventilation, without taking ETI out of the hands of paramedics. The use of alternative or rescue devices such as laryngeal mask airway or esophageal obturator devices should be considered in services that use ETI, especially in the setting of sedative facilitated or RSI aided intubation. Training in airway techniques with practice sessions either in the operating room or with simulators should be offered to help paramedics maintain a satisfactory skill level.

The available evidence might seem to point toward removing ETI from the paramedic scope of practice, but the issue is more complex than that. Rather than striking ETI from the paramedic armamentarium, selective use of paramedic ETI should be based on very specific protocols and parameters. Taking a life saving intervention out of the hands of paramedics would be reprehensible. As emergency physicians we need to continue to provide evidence based direction with regard to what circumstances ETI should and should not be used. The fact that there is significant evidence to suggest that paramedics with better training and oversight are better at airway management should serve as a call to all emergency physicians to participate in the training and oversight of prehospital providers.

References:
1. 2005 American Heart association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care, Circulation, (suppl) Vol 112, No. 24, December 13, 2005
2. Bulger Et Al, An Analysis of Advanced Prehospital Airway Management Journal of Emergency Medicine,Vol 23, Issue 2, August 2002
3. Wang HE, Yealy DM, How Many Attempts Are Required To Accomplish Out-of-Hospital Endotracheal Intubation ?, Academic Emergency Medicine,13:(4)372-377, 2006
4. Gausche M, Lewis RJ, et al. Effect of Out-of Hospital Pediatric Endotracheal Intubation on Survival and Neurological Outcome A Controlled Clinical Trial, JAMA, 2000; 283(6) 783-90
5. Davis DP, Hoyt DB, et al. The effect of paramedic rapid sequence intubation on outcome in patients with severe traumatic brain injury, J Trauma, 2003; 55(4) 713-9
6. Orebaugh SL. Difficult airway management in the Emergency Department. J Emerg Med. January 2002; 22:31-48
7. Fakhry SM, Scanlon JM, Prehospital Rapid Sequence Intubation for Head Trauma: Conditions for a Successful Program, J Trauma 2006; 60:997-1001
8. Dunford JV, Davis DP, Ochs M, Doney M, Hoyt DB, Incidence of Transient Hypoxia and Pulse Rate Reactivity During Paramedic Rapid Sequence Intubation, Ann Emerg Med. 2003; 42:721-728
9. Swanson ER, Fosnocht DE, Neff RJ, The Use of Etomidate for Rapid-Sequence Intubation in the Air Medical Setting, PEC 2001; 5: 142-146
10. Davis DP, Kimbro TA, Vilke GM, The Use of Midazolam for Prehospital Rapid-Sequence Intubation May be Associated with a Dose- Related Increase in Hypotension, PEC 2001; 5: 163 – 168
11. Wang HE, Kupas DF, Paris PM, Bates RR, Yealy DM, Preliminary experience with a prospective multi-centered evaluation of out-of hospital endotracheal intubation, Resuscitation, Vol 58 Iss 1, July 2003 pp. 49-58
12. Jacobs LM, Berrizbeitia LD, Bennett B, Madigan C, Endotracheal intubation in the prehospital phase of emergency medical care. JAMA, 1983; 250:2175-7
13. Wang HE, Yealy DM, How Many Attempts Are Required to Accomplish Out-of-hospital Endotracheal Intubation? Academic Emergency Medicine 2006; 13:372-377
14. Ochs M, Davis D, Hoyt D, Bailey D, Marshall L, Rosen P, Paramedic-Performed Rapid Sequence Intubation of Patients With Severe Head Injuries, Ann Emerg Med. August 2002; 40:159-167
15. Wang HE, Kupas DF, Hostler D, Cooney R, Yealy DM, Lave JR, Procedural experience with out-of hospital endotracheal intubation, Crit Care Med 2005; Vol 33, No. 8.
16. Fakhry SM, Scanlon JM, Robinson L, Askari R, Watenpaugh RL, Fata P, Hauda WE, Trask A, Prehospital Rapid Sequence Intubation for Head Trauma: Conditions for a Successful Program, J Trauma. 2006;60:997-1001

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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